Evariste have performed in silico modelling of cancer dependency data to identify the next generation of druggable synthetic lethal gene pairs utilizing XDel knockout cells
We have prioritised gene pairs with a rational mechanism linking the target and biomarker, and with patient populations with high levels of unmet need
These pairs reflect both pan-cancer and highly lineage specific relationships
We have validated >10 of these relationships across multiple cell lines to give high confidence in the validity of the novel pairs
For one gene pair with a kinase as the druggable node we have generated novel inhibitors with best-in-class selectivity over the SL partner and properties suitable for in vivo dosing and validated the specific targeting of biomarker low cell lines
